Nyxoah ™
Intro/Problem Statement:
When Sleep Stops, Life Stops
Sleep is essential for the mind, body, and heart to recharge. For millions with Obstructive Sleep Apnea (OSA), however, nights are fragmented by snoring, gasping, choking, or pauses in breathing that starve the body of oxygen. Days become a fog of fatigue, irritability, memory lapses, and reduced quality of life. Traditional CPAP therapy has saved lives, but many patients find it uncomfortable or intolerable, leaving them with few effective alternatives.
Nyxoah’s Genio® system offers a new approach: battery-free, leadless, minimally invasive hypoglossal nerve stimulation that restores natural breathing during sleep, without bulky equipment or discomfort.
How It Works / Trial
Patients first undergo a consultation, sleep study, and anatomical assessment. A minimally invasive procedure implants the device, which is activated after a short healing period. Clinicians then fine-tune stimulation settings over several nights for optimal comfort and efficacy.
Solution:
What Is Genio®
Genio® is a neuromodulation therapy that stimulates the hypoglossal nerve, activating tongue and airway muscles to keep the airway open. Unlike CPAP, it works with the body rather than forcing air. The system combines:
- Implantation: A small, battery-free device placed under the chin through a single incision.
- External activator: A lightweight wearable powers and controls stimulation during sleep.
- Bilateral stimulation: Both sides of the nerve are engaged for stable, symmetrical airway opening.
- Gentle muscle activation: Moves the tongue forward and stabilizes surrounding muscles, preventing airway collapse without waking the patient.
This design offers simplicity, safety, and patient comfort.
What Is Different About Medtronic Options
Medtronic emphasizes breadth and innovation in pain care. Their SCS systems feature advanced technologies such as closed-loop stimulation, rechargeable designs, and full-body MRI compatibility—important considerations for patients managing chronic conditions over many years. Medtronic also offers additional pain therapies, such as Targeted Drug Delivery, allowing care teams to tailor treatment when stimulation alone is not enough.
Who Can Benefit
Genio® is suited for adults with:
- Moderate to severe OSA (AHI 15–65)
- Clear anatomical suitability for hypoglossal nerve stimulation
- Documented CPAP failure or intolerance
Desire for a mask-free, minimally invasive treatment
Patient Testimonial
Hearing real patients describe improved sleep, energy, and quality of life helps make the therapy relatable and reinforces its impact.
Benefits of Genio®
- Improved sleep quality: Fewer apnea events and micro-awakenings
- Enhanced daytime energy, mood, and cognition
- High adherence: Comfortable, mask-free therapy that integrates into daily life
- Long-term reliability: Battery-free, leadless implant reduces hardware issues and avoids replacement surgeries
Bilateral stimulation: More consistent airway patency than unilateral devices
Conditions Treated
Moderate to severe OSA, especially in patients who cannot tolerate CPAP or prefer a less intrusive solution.
Genio® Implant
Visual assets help patients understand the procedure and recovery process.
Steps to Treatment:
- Consultation & Evaluation: Sleep specialist reviews history, imaging, and prior CPAP experience.
- Implantation: Minimally invasive outpatient procedure.
- Activation & Optimization: External wearable powers stimulation; settings adjusted for comfort and efficacy.
- Long-Term Monitoring: Optional follow-up sleep studies and symptom assessment ensure ongoing success.
Resources
Patient Brochure
Conclusion: Genio® is more than a device, it restores natural sleep, comfort, and daily vitality. For those struggling with CPAP or sleepless nights, it offers a new dawn: safe, effective, and life-changing therapy for OSA.